RESEARCH PEPTIDE • LABORATORY USE ONLY
MK-677
Growth Hormone Secretagogue
$119
FOR RESEARCH USE ONLY. This product is intended for laboratory and research applications only. Not for human consumption, clinical, diagnostic, or therapeutic use. Purchaser assumes all liability.
Research Overview
MK-677, also known as Ibutamoren, is a potent, selective, orally-active growth hormone secretagogue and ghrelin receptor agonist. This non-peptide research compound stimulates growth hormone (GH) release through activation of the ghrelin receptor (GHSR), mimicking the endogenous hormone ghrelin.
Originally developed by Reverse Pharmacology and later acquired by Merck, MK-677 has been extensively studied in preclinical and clinical research settings for its effects on growth hormone pulsatility, IGF-1 levels, and various metabolic parameters in controlled laboratory environments.
Research Applications
GH/IGF-1 Axis Studies
Laboratory research examines MK-677's stimulation of pulsatile growth hormone secretion and sustained elevation of IGF-1 levels in various experimental models without affecting cortisol levels.
Metabolic Research
Preclinical studies investigate effects on nitrogen balance, basal metabolic rate, and body composition parameters in controlled research environments.
Bone Density Models
Research protocols examine markers of bone turnover, osteoblast activity, and mineral density in laboratory settings focused on skeletal biology.
Sleep Architecture Studies
Clinical research has investigated effects on REM sleep duration and sleep quality parameters in various study populations.
Specifications
Storage & Handling
Store powder form at room temperature in a cool, dry place protected from light and moisture. MK-677 mesylate is relatively stable as a powder and does not require refrigeration or freezing for long-term storage.
When reconstituting for research applications, dissolve in appropriate vehicle (DMSO, PEG-400, or other suitable solvent depending on experimental protocol). Prepared solutions should be stored at 2-8°C and used within recommended timeframes based on solvent used.
Selected References
1. Svensson J, et al. "The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats." J Endocrinol. 2000;165(3):569-577.
2. Chapman IM, et al. "Effect of oral administration of growth hormone (GH) secretagogue MK-677 on 24-hour GH profiles in healthy older adults." J Clin Endocrinol Metab. 1997;82(8):2793-2800.
3. Nass R, et al. "Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults." Ann Intern Med. 2008;149(9):601-611.